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Phenytoin Ikapharmindo

Phenytoin Ikapharmindo

phenytoin

Manufacturer:

Ikapharmindo
Concise Prescribing Info
Contents
Phenytoin Na
Indications/Uses
Cap: Control tonic & psychomotor epilepsy attack. Inj: Status epilepticus; prevention & treatment of seizures in neurosurgery.
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Dosage/Direction for Use
Cap Adult Initially 300 mg in 2 divided doses. Maintenance: 300-400 mg daily. Max: 600 mg. Childn Initially 5 mg/kg/day in 2 divided doses. Maintenance: 4-7 mg/kg/day. Inj Status epilepticus 150-250 mg slow IV (at a rate not exceeding 50 mg/min), followed by 100-150 mg if necessary 30 min later. Prevention of seizures during neurosurgery 100-200 mg IM at 4 hr intervals during surgery & continued during the post-op period.
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Overdosage
View Phenytoin Ikapharmindo overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food: When administering to patients on nasogastric or other enteral feeds, do not administer feeds 2 hr before or after a dose. Be consistent throughout therapy in relation to feed times. Swallow cap whole, do not open/chew/crush. Do not switch dosage forms/brands w/o prior consideration.
Contraindications
Hypersensitivity to phenytoin or other hydantoin. Inj: Sinus bradycardia.
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Special Precautions
Avoid abrupt w/drawal. Blood dyscrasia. Liver dysfunction. Not for hypoglycemia-caused attack. May impair ability to drive &/or use machinery. Pregnancy & lactation. Cap: Not to be given to petit mal patients. Discontinue if skin rash occurs. Elderly.
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Adverse Reactions
Nausea, vomiting, constipation, hepatitis; nystagmus, ataxia, speaking difficulty, tremors, confusion, dizziness, insomnia, morbilliform rash; SLE, lymphadenopathy, leukopenia, thrombocytopenia, agranulocytosis, megaloblastic anemia. Cap: SJS, diplopia, bone marrow depression. Inj: Nervousness, motor twitching, headache; liver damage; granulocytopenia, pancytopenia, macrocytosis; coarsening of the face, enlargement of the lips, gingival hyperplasia, hypertrichosis, Peyronie's disease; periarteritis nodosa; hypersensitivity reactions, abnormal Ig.
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Drug Interactions
Enhanced effect w/ amiodarone, chloramphenicol, chlordiazepoxide, diazepam, dicoumarol, disulfiram, halothane, INH, phenyramidol, sulthiamine, viloxasine, thyroid prep. Decrease plasma level of carbamazepine, ethosuximide, valproic acid & promidone. Reduced effects w/ alcohol & phenobarb. May impair efficacy of corticosteroids, digitoxin, disopiramide, mexiletine, quinidine, meperidine, methadone, cyclosporine, doxycycline, furosemide, rifampicin, theophylline, estrogens, OCs, oral anticoagulants, vit D. Inj: Increased serum level w/ methylphenidate, phenothiazines, phenylbutazone, salicylates, ethosuximide, sulfonamides, tolbutamide, trazodone, estrogens, H2-antagonists, acute alcohol intake. Decreased serum level w/ chronic alcohol abuse, reserpine, sucralfate. May increase or decrease phenytoin serum level w/ phenobarb, Na valproate, valproic acid. TCA may precipitate seizure. Impaired efficacy of coumarin.
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Storage
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Description
View Phenytoin Ikapharmindo description for details of the chemical structure and excipients (inactive components).
Action
View Phenytoin Ikapharmindo mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Anticonvulsants
ATC Classification
N03AB02 - phenytoin ; Belongs to the class of hydantoin derivatives antiepileptics.
Presentation/Packing
Form
Phenytoin Ikapharmindo cap 100 mg
Packing/Price
100's (Rp55,000/pak)
Form
Phenytoin Ikapharmindo inj 50 mg/mL
Packing/Price
(amp) 2 mL x 10 × 1's (Rp509,140/boks)
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